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2016年6月30日 讯 /生物谷BIOON/ --如果被问及有害的肠道细菌会引发什么问题，大多数人或许都认为有害肠道菌群会引发消化道问题，比如便秘、胃胀气或腹泻；但近日科学家们发现，有害细菌，或有益细菌水平不够或许和多发性硬化症发生直接相关，相关研究发表于Scientific Reports杂志上。 Ashutosh Mangalam博士表示，人类机体肠道中携带着数万亿个细菌，俗称为肠道微生物组，近年来多项研究表明，肠道菌群在改善并维持人体健康上扮演着重要作用。肠道细菌往往机体健康息息相关，为此研究人员就想知道是否肠道菌群和慢性自身免疫性疾病直接相关，比如多发性硬化症等，同时研究者还想知道是否自身免疫性疾病患者机体的肠道微生物组不同于健康个体的肠道微生物组。 研究者表示，实际上多发性硬化症患者有着和健康个体不同的肠道微生物组，尽管这是一项初步研究，但相关数据表明，多发性患者机体中有益菌群的水平较低，比如那些从健康食物（黄豆、亚麻）中获取效益的有益菌群。 研究者Mangalam和来自梅奥诊所的的研究者对来自多发性硬化症患者的粪便样本进行微生物组分析，同时以健康个体作为对照；结果表明，相比对照健康个体而言，多发性硬化症患者机体中特定菌群的水平降低或升高了；后期研究中研究者表示，他们还将通过对大量研究对象进行更为深入的研究来证实本文中的研究发现。（生物谷Bioon.com） 本文系生物谷原创编译整理，欢迎转载！点击 获取授权 。更多资讯请下载生物谷APP.
doi:10.1038/srep28484
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Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
Jun Chen, Nicholas Chia, Krishna R. Kalari, Janet Z. Yao, Martina Novotna, M. Mateo Paz Soldan, David H. Luckey, Eric V. Marietta, Patricio R. Jeraldo, Xianfeng Chen, Brian G. Weinshenker, Moses Rodriguez, Orhun H. Kantarci, Heidi Nelson, Joseph A. Murray & Ashutosh K. Mangalam
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
