） 摘要： 本文应用MTT比色法及流式细胞术研究四种水杨醛氨基酸Schiff碱铜配合物（6B、7B、6P和7P）对BGC823胃癌细胞系和HeLa宫颈癌细胞系的抑制生长和诱导凋亡作用
不同种类的配合物对BGC823细胞和HeLa细胞的生长增殖均有明显的抑制作用
四种配合物均促使细胞发生凋亡
） Abstract： To study the anti-proliferation and inducing apoptosis effects of four copper ternary coordination compounds of the salicylidene-amino acid Schiff base(6B,7B,6P and 7P)on human gastric carcinoma cells BGC823 and human cervical carcinoma cells HeLa through MTT assay and the flow cytometry(FCM)
Our study showed that the proliferation of BGC823 cells and HeLa cells were significantly inhibited by the four Schiff base complexes (6B,7B,6P and 7P)and the inhibition rates were concentration-dependent
FCM analysis showed the cells of drug treatment groups had higher apoptosis index(AI) and the effects were concentration-dependent
The phases of cell cycle were also changed: the percentage of cells in G0/G1 phase decreased, and the cells in G1/S and G2/M phase increased
Keywords： Sciff base,salicylidene-amino, apoptosis,BGC823 cells, HeLa cells 下载PDF阅读器 PDF全文下载： 初稿 （ 285 ） 作者简介： 通信联系人： 【收录情况】 中国科技论文在线： 郭爱娟
水杨醛氨基酸Schiff碱铜配合物体外抗肿瘤作用[EB/OL]
北京：中国科技论文在线
HeLa细胞 Guo Aijuan * （ School of Life Science and Technology
