TGF-β1与促炎细胞因子IL-1β协同活化子宫内膜间质细胞Smad2信号通路[EB/OL]
北京：中国科技论文在线
结论：TGF-β1和IL-1β均能上调ESCs细胞表达Smad2,且两者对ESCs细胞Smad2信号通路的活化具有协同作用
） 摘要： 目的：探讨转化生长因子-β1(TGF-β1)和促炎细胞因子白介素-1β(IL-1β)对子宫内膜间质细胞Smad2信号通路的影响
用不同浓度的外源性TGF-β1和或IL-1β细胞因子处理ESCs细胞
（2）TGF-β1和IL-1β能够协同作用促进ESCs细胞表达Smad2
） Abstract： Objective: To investigate the effect of TGF-β1 and IL-1β on Smad2 signal pathway in ESCs cells
Methods: The endometrial stromal cells(ESCs) were separated from eutopic endometrium of endometriosis patients, the ESCs were treated with different concentrations of exogenous TGF-β1 or and IL-1β
The expression of transcription factor Smad2 were analysed by In cell weatern
Results: (1) TGF-β1 and IL-1β both could promote ESCs cells to express Smad2 in a concentration-dependent manner
(2) TGF-β1 and IL-1β have synergistic role to up-regulate ESCs cells expressing Smad2
Conclusion: TGF-β1 and IL-1β both could activate ESCs cells Smad2 signal pathway and they have a synergistic effect, which maybe change the biological activity of ESCs cells, conducive to the growth of ESCs cells in ectopic milieu, contributing to the onset and development of endometriosis
Keywords： Obstetrics & Gynecology; endometrial stromal cells; Transforming growth factor-β1; Interleukin-1β; endometriosis 下载PDF阅读器 PDF全文下载： 初稿 （ 43 ） 作者简介： 王晓秋(1980年-),女,住院医师,主要研究方向:生殖免疫与生殖内分泌 通信联系人： 李大金(1957-),男,教授,主要研究方向:生殖免疫与生殖内分泌 【收录情况】 中国科技论文在线： 王晓秋
结果：（1）TGF-β1和IL-1β均能以浓度依赖的方式促进ESCs细胞表达Smad2
