REGγ的生理病理功能研究进展[EB/OL]
北京：中国科技论文在线
REGγ在机体正常的生长发育和病理发生发展中发挥重要的生物学功能
主要研究方向：肿瘤机制 通信联系人： 【收录情况】 中国科技论文在线： 党永岩
REGγ还通过CK-1δ(casein kinase 1δ)-MDM2(mouse double minute 2 homolog )-p53信号通路参与衰老的调控
参与细胞周期的调控
Li Xiaotao 3, （ 1、 School of Life Science, East China Normal university
） Abstract： REG gamma (REGγ) is a new type of activator of proteasome
It can form a ring of homoheptamer as the caps of proteasome
REGγ can promote the degradation of p21, p19, p16 and p53 in a ubiqutin dependent/independent manner and involve in the regulation of cell cycle
Sumolyation and acetylation of REGγ are necessary for its degradation to its targets
REGγ can regulate aging through CK-1δ (casein kinase 1δ)-MDM2 (mouse double minute 2 homolog)-p53 signal pathway
REGγ exhibits dramatic autophagy induction and Sirt1 (sirtuin 1) degradation and thus protects against high-fat diet-induced disorder of lipid metabolism
REGγ acts as an oncogene in thyroid cancer, lung cancer, liver cancer and breast caner
Interestingly, it can degrade the oncogenic proteins such as SRC3 (steroid receptor coactivator-3) and PTTG1 (pituitary tumor-transforming gene 1), indicating its dual functions in cancer
All the researches showed that REGγ plays a critical role in the regulation of normal development and pathology process
Keywords： REGγ
2、 School of Life Science, East China Normal University
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