雷帕霉素联合地塞米松抑制mTOR/p70S6K通路逆转Raji细胞对雷帕霉素和糖皮质激素耐药的研究[EB/OL]
北京：中国科技论文在线
结论 mTOR激酶激抑制剂雷帕霉素联合地塞米松能同时逆转Raji细胞对雷帕霉素和糖皮质激素耐药
方法 用mTOR抑制剂雷帕霉素和/或地塞米松处理Raji细胞
其分子机制是雷帕霉素和GC协同上调细胞周期调控蛋白p21waf1和p27kip1的表达
单用雷帕霉素或地塞米松不能有效抑制p-p70S6K表达
MA Zhigui 2, （ 1、 Laboratory of Hematology/Oncology, Department of Pediatric Hematogly, West China Second University Hospital, Sichuan University, ChengDu 610041
结果 Raji细胞缺失mTOR信号传导通路下游蛋白4E-BP1表达
2、 Laboratory of Hematology/Oncology, Department of Pediatric Hematogly, West China Second University Hospital, Sichuan University, Chengdu 610041
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